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  3. January 2023

January 2023

GRP78 as a Target for Prevention of Age-related Cataract By Regulation of Reticulum Endoplasmic Stress

Nugraha Wahyu Cahyana
Nugraha Wahyu Cahyana Jember University

Abstract

Cataract is the most common causes of blindness worldwide. The most common kind of cataract is age-related cataract. Measures to prevent the development of cataracts are urgently needed. Significant data suggests that increased endoplasmic reticulum stress is a significant role in cataract development. The goal of this review is to investigate the involvement of endoplasmic reticulum as a factor in cataracts caused by the buildup of unfolded proteins from lens epithelial cells. GRP78 is one of the key signs of endoplasmic reticulum stress, and it promotes the UPR to limit the increase in unfolded protein levels. The significance of GRP78 signaling in cataract prevention is discussed in this paper.

Keywords:

Cataracts, reticulum endoplasmic stress, GRP78, UPR

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